Landstalker is awesome, sorta like zelda
Shadow run , better then snes ver !
Sword of Vermilion - pretty cool action rpg
UMK3 - Runs perfect , and imo looks better then snes (on picodrive anyway) theres also a hack called UMK trilogy also,has alot more characters and extra moves ,fatalitys etc and im pretty sure its the biggest megadrive rom made
Dune 2 - classic RTS
Castlevania bloodlines - its castlevania!
Desert Strike - and its sequels
King Bounty - fun turn based game
Shining force I and II
Two Crude Dudes