I made a port of Mednafen previously a while back and unfortunately it was quite slow so i disabled the VB core in later releases.
That said, mednafen itself was pretty unefficient and bloated so what i could do for the VB core is to take the libretro's core like i did for VBA Next, Mednafen's wonderswan core etc... and make it standalone.
It's possible but it requires quite some work unfortunately. I have it planned on my TODO list.