A while back I tried Destruction Derby, GT Racing '97, Trackattack, Carmageddon and Screamer in dosbox on the Zero. The first three loaded and menus worked fine but in-game framerate was slow (unplayable). I don't know if the joystick is detected in those games but the arrow keys are used to accelerate & steer so the d-pad allowed movement without messing with the virtual keyboard. Carmageddon froze on level loading screen and Screamer wouldn't load at all. However I later had these same problems on my pc, failure to load up, bad frame-rate or crashing upon selection. I forgot what I did to get them running well, it's hard enough on the pc and I'm no leet hax0r. It's less painful simply having a computer from the 1990s which you can dedicate to retro gaming because otherwise you either have to mess with cpu cycles and all that in dosbox, or explorer.exe and backwards-compatibility in Windows 7.
Keep in mind that some old games have held up better than others. Most are not worth the time investment it takes to get them running. Of course network play can bring new life into any mediocre game and one of the benefits of the Zero is that it offers a standardized platform for finding solutions. Playing first person shooters on a portable system is great, playing Driver or Hydro Thunder would be better. And yes that did get a PC release (in Europe), you can buy it on Amazon, they also released "Midway Arcade Treasures: Deluxe Edition."
If there isn't one already us Zero owners could use a website or thread similar to Wine's database where people list what games run and what they did to run them.