There's only a Python interpreter, so speeds won't be great.
If want to Dive Into Python then we first need a good MIPS compiler for it, like PyPy.
Try porting that first and a whole ton of games would suddenly become available for GCW0.
If only Yoyogames would support the GCW-Zero in GMStudio. I've created quite a few games with GameMaker, and it would be great if I could port them, but it's not possible.
Something like this would be great though. I haven't seen a whole lot of Python games. Small games like chess and such, sure, but are there any large Python games?