Please, no more requests like these because it is just ridiculous.
As congusbongus said, it is not possible without the game being open source, which means the developers themselves have to port it to GCW Zero, which quite frankely, is unlikely.
But perhaps you could try to convince them to do the port ?
Also, even in the case when it actually gets ported, it will not run smoothly due to how much CPU time the game engine takes...
I mean, seriously... The Binding of Isaac : Rebirth runs like a dog on old hardware, even though it is not very impressive.
Another alternative might be to port LightSpark to the handled so we can play The binding of Isaac (the first, not rebirth) to the GCW Zero.
But i doubt Lightspark can actually play the game...
Or the more likely solution : Port SFML and then Witch Blast.